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3 edition of The effect of irradiation on delayed hypersensitivity and antibody formation in rats. found in the catalog.

The effect of irradiation on delayed hypersensitivity and antibody formation in rats.

Risto Visakorpi

The effect of irradiation on delayed hypersensitivity and antibody formation in rats.

by Risto Visakorpi

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  • 20 Currently reading

Published by Department of Serologyand Bacteriology, University of Helsinki in Helsinki .
Written in English


ID Numbers
Open LibraryOL21259540M
ISBN 109519901671
OCLC/WorldCa58517718

Axelrad, M. A.: Suppression of delayed hypersensitivity by antigen and antibody. Is a common precursor cell responsible for both delayed hypersensitivity and antibody formation. Immunol. 15, () Google Scholar.   Type IV hypersensitivity is involved in the pathogenesis of many autoimmune and infectious diseases (tuberculosis, leprosy, blastomycosis, histoplasmosis, toxoplasmosis, leishmaniasis, etc.) and granulomas due to infections and foreign antigens. Another form of delayed hypersensitivity is contact dermatitis (poison ivy (figure 6), chemicals, heavy metals, etc.) in which the lesions are more.

Antibody response to SRBCs is eliminated for about 1 month following TLI. Subsequently, IgM is produced, but {gG is not seen until about 7 months following TLI, and then it is produced at reduced levels. Irradiation of the thymus or subdiaphragmatic tissue has only a small effect on the response to SRBCs (Strober et al., Delayed Type Hypersensitivity: The primary T cell involved in the granuloma formation can be either a CD4+ or CD8+ T cell, depending on the nature of the antigen. CD4+ cells regulate the response to protein and extracellular pathogens. [] An obvious effect of UV irradiation is the depletion of Langerhans' cells.[33].

  Classification of Hypersensitivity reactions I. Immediate hypersensitivity (B cell or Ab mediated) Anaphylaxis Atopy Antibody mediated cell damage Arthus phenomenon Serum sickenss II. Delayed hypersensitivity (T cell mediated) Infection (tuberculin) type contact dermatitis type Mohammad Mukhit Kazi Lecturer SDCH Pune 9. Germinal Centers in Immune Responses by Hans Cottier, , available at Book Depository with free delivery worldwide.


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The effect of irradiation on delayed hypersensitivity and antibody formation in rats by Risto Visakorpi Download PDF EPUB FB2

The effect of x-irradiation on delayed hypersensitivity and circulating antibody in the rat. Bowser RT, Spence DB, Exum ED. PMID: [PubMed - indexed for MEDLINE] MeSH Terms. Animals; Antibodies/radiation effects* Antibody Formation/radiation effects* Antigens; Freund's Adjuvant; Hypersensitivity, Delayed* Immunity, Cellular/radiation Cited by: 1.

The effect of whole body x-irradiation on delayed hypersensitivity in the rat. Visakorpi R. PMID: [PubMed - indexed for MEDLINE] MeSH Terms.

Animals; Antibody Formation/radiation effects* Hypersensitivity, Delayed* Male; Radiation Effects* Rats; Serum Albumin, Bovine; Skin Tests; Time Factors; Substances. Serum Albumin, BovineCited by: 2. The effect of total body irradiation on the development of delayed hypersensitivity and on the febrile response to specific antigen has been studied in guinea-pigs with the following results: 1.

whole body irradiation in guinea-pigs, while suppressing circulating antibody response, did not prevent the development of delayed : Ingrid V. Allen. Whole body irradiation with rads suppressed humoral and cell-bound immune responses in rats.

Rats were immunized with bovine serum albumin 24 hr a Cited by: 2. Eltringham, J. R., and Weissman, I. L.,Differential effects of local lymphoid irradiation on delayed hypersensitivity and the serum antibody response in rats: Antigen injection before x-rays, J.

Immunol PubMed Google ScholarCited by: The Effect of Irradiation on the Fever of Delayed Hypersensitivity. Author(s): Allen, I. Journal article: Immunology Vol.8 No.5 pp ref 1. Acta Pathol Microbiol Scand B Microbiol Immunol.

;80(6) Effect of irradiation on established delayed hypersensitivity. Suppression of skin reactions, recovery and the effect of. EFFECT OF X-RAY LYMPHOPENIA ON CONTACT DERMATITIS. FAILURE OF WHOLE-BODY X-IRRADIATION TO INHIBIT THE DELAYED HYPERSENSITIVITY CHALLENGE RESPONSE IN THE GUINEA PIG.

Arch Dermatol. Dec; – Möller G, Möller E. Plaque-formation by non-immune and x-irradiated lymphoid cells on monolayers of mouse embryo cells.

Nature. Delayed Hypersensitivity Mechanism of Cellular to Injection G. MACKANESS and the Resistance Trudeau Institute, Saranac Lake, New York Its frequent association with the infective process enabled Zinsser in (I) to separate delayed hypersensitivity from other types of allergic reaction.

Delayed skin hypersensitivity to ovarian tissue was followed by the appearance of anti-ovary antibody in the circulation. Effects of brain lesions on antibody production, Arthus reactivity and.

CF1 mice or COBS rats were exposed to a single dose of R total-body X-irradiation at various times during the course of infection with Trypanosoma cruzi. The effect of this dose of X-irradiation on the parasitemia, numbers of tissue parasites, and mortality in young mice and rats was studied.

Irradiation of mice and rats 3 days prior to intraperitoneal inoculation of or Injecting culture supernatants from UV-irradiated keratinocytes into normal mice produced the same effect as whole-body UV irradiation and suppressed the induction of delayed hypersensitivity to.

In initial testing, we found no evidence of altered natural killer cell activity, T cell-mediated delayed-type hypersensitivity, or specific antibody formation in male rats given either a mg.

The effect of whole-body irradiation on cellular immunity, as measured in vivo by delayed-type hypersensitivity (DTH) to oxazolone (4- ethoxymethylene phenyl- oxazol. The role of lymphocytes in antibody formation.

The influence of lymphocyte migration on the initiation of antibody formation in the isolated, perfused spleen. in the delayed hypersensitivity reaction: An autoradiographic study.

J Immunol –, PubMed Google Scholar. Hall JG, Morris B. Effect of x-irradiation of the. REFERENCES Askenase PW, Hayden BJ, Gershon RK () Augmentation of delayed-type hypersensitivity by doses of cyclophosphamide that do not affect antibody synthesis. J Exp Med Bash JA, Singer AM, Waksman BH () The suppressive effect of immunization on the proliferation responses of rat T cells in vitro II.

Nagareda, C. S.,Antibody formation and the effect of x-irradiation on circulatory antibody levels in the hypophysectomized rat, J.

Immunol. PubMed Google Scholar. This chapter discusses the effect of viral infections on the function of the immune system. Immunologic dysfunction induced by virus must reflect changes in the physiologic and immunologic function of T (thymus-dependent) lymphocytes, B (thymus-independent) lymphocytes, or macrophages, as it is the interaction between these cells and their products that generates immunity.

Irradiation affects the cell-mediated response by inhibiting immunization and delayed hypersensitivity reactions when administered before antigen. Because the cell-mediated response involves nonlymphoid cells whose precursors are also radiosensitive, irradiation following stimulation may also produce temporary suppression.

Type IV hypersensitivity is also called delayed-type hypersensitivity (DTH) because the tissue reaction usually occurs 24 to 48 hours after exposure to antigen. Type IV hypersensitivity is a cell-mediated immunoreaction that is dependent on the presence of a significant number of primed, antigen-specific T cells (see Fig.

D). Moreover, the results show that ozone can also have a suppressive effect on the development of cellular immune responses to a respiratory Listeria infection, i.e., on T/B ratios in lung draining lymph nodes, delayed-type hypersensitivity responses to Listeria antigen, and lymphoproliferative responses in spleen and lung draining lymph nodes to.By delayed-type hypersensitivity or by antibody responses, by any criteria.

The supposed immune-responsiveness genes were thought at one stage to be the receptor on T lymphocytes – the T-cell receptor for antigen – because they generally acted in the case of cell-mediated immunity or helping antibody formation.Delayed hypersensitivity reactions are generally characterized as contact dermatitis or infection allergies.

Immediate hypersensitivity. The reactions accompanying immediate hypersensitivity depend upon the nature of the antigen, the frequency and route of antigen contact, and the type of antibody reacting with the antigen.